Login or Register






Lost Password?
No account yet? Register
Essential Sugars

When you cut your hand, how do your skin and other tissue know how to fill in the damaged area and seal itself off again? When you eat, how does your digestive tract know which food components to grab and send into the blood stream and which ones to allow to passes through? How do the filters in your kidneys choose the correct molecules to expel? Unlike machines, living organisms are coded to perform many complex "involuntary" functions. The more complex the organism, the more such functions it must perform to live and thrive.

Science and medicine have long tried to break the biocode by which the cells of the body communicate with one another in order for these complex functions to occur. This mysterious code is truly the language of life. Biochemistry is the chemistry of life. It is the science concerned with the various molecules found in living cells and organisms and with their chemical reactions. The aim of biochemistry is to explain, in molecular terms, the chemical processes of living cells.

The four major classes of biomolecules are proteins, nucleic acids, lipids (fats) and carbohydrates. For many years, scientists focused on proteins as the primary communication molecules. Early in this century, however, a theoretical mathematician at the Weisman Institute calculated the number of molecular configurations possible with protein molecules and the number of known chemical command signals needed to run the body. She concluded that there were not enough protein configurations possible to supply all the messages. Another code was required.

RESEARCH ON GLYCOPROTEINS AND THE CODE OF LIFE

In the 1960s, research first began to appear on glycoproteins, protein molecules bound with carbohydrate molecules. ("Glyco" means "sweet" and refers to sugars or carbohydrates or saccharides.) Glycoprotein molecules coat the surface of every cell with a nucleus in the human body. Glycolipids, carbohydrate molecules bound with lipid (fat) molecules, are another kind of glyconutrient or glycoconjugate found on cell surfaces. In Figure A below the hair-like strands protruding from the section of cell surface are glycoproteins. The gold component represents protein molecules; the red component represents carbohydrate molecules.

FIGURE A

Figure 1 is drawn after the 1996 covers of Glycobiology: Official Journal of the Society of Glycobiology, Oxford University Press. The journal acknowledged permission to reprint the original illustration from Oxford GlycoSystems, Ltd.

We now know that nature uses the carbohydrates on cell surface glycoconjugates as communication (or recognition) molecules. Carbohydrates are much more structurally complex than the simpler proteins. Many more molecular configurations are possible with a six-carbon sugar (e.g. glucose), which has two isometric forms and six binding sites. For example, while only 24 oligopeptide configurations are possible with four peptides (proteins), more than 1000 different oligosaccharide configurations are possible with four carbohydrate molecules.1 (p 477) So carbohydrate molecules provide the most specific form of biological information for the code of life.

The study of glyconutrients has grown exponentially as the technological means to conduct the studies have been developed. Based on this research, by 1996 scientists had identified eight specific sugar forms found on human cell surface glycoforms that are involved in cellular recognition processes.2 (p 677)

For illustration purposes, molecular communication codes can be thought of like our own written language. Just as four different shapes can be combined to make many letters, and these letters can be combined to make many words, the different carbohydrate molecules combine within our bodies to make many cellular recognition "words". These precisely shaped words protrude from cell surfaces and are recognized and understood (or not understood) by neighbouring cells through the “sense of touch”.

Enzymes are the tools the body uses to build the glyco-portion of glycoforms.

The effectiveness of the enzymatic conversion system to create the needed sugar molecules is not absolute. First, some individuals have inborn errors of metabolism. This means these individuals may be missing one or more of the enzymes needed to make the conversions. The conversion process also requires specific vitamins at certain steps, and these vitamins may be missing in the diet. Finally, the conversion process requires time and energy. Each step in the enzymatic conversion process for these sugars creates a new substrate that is one step closer to the needed molecule. It is therefore clear that the closer the substrate provided is to the required end-product, the fewer steps the enzymatic conversion system has to take and the more the system will function at optimal capacity.

Of the required eight sugars glucose, galactose, mannose, fucose (not fructose), xylose, N-Acetylglucosamine, N-Acetylgalactosamine, N-Acetylneuraminic acis / sialic acid named in Harper’s Biochemistry, involved in the formation of glyconutrients, only glucose and galactose are freely available in the modern-day diet. Clearly indicating possible deficiency of glyconutrients.

SOURCES OF GLYCONUTRIENTS

Ultimately, only plants can capture the sun’s energy to produce the carbohydrates required by the body. Thus, the plants in our diet are the primary building blocks for the sugar portion of these molecules that are so vital to continued good health. A healthy body can break down plant carbohydrates, restructure them into small sugars, then use those sugars to build the glycoforms required for accurate cellular communication and resultant good health.

You can adapt your diet to improve supply of “essential” sugars or supplement for a period of time to “catch up” on a deficiency. But remember there is no “magic bullet” in fixing health problems. No single nutrient or supplement, will deliver “good health” without the hard work of changing your total diet to a more nutritious one, full of its own synergistic forces. While “essential” sugars are very important to health, so are the other more than 90 essential nutrients.

Mannose

Aloe vera (acemannan is a chain of mannose molecules), kelp, shiitake mushroom, ground fenugreek, carob gum, guar gum, black currants, red currants, gooseberries, green beans, capsicum (cayenne pepper), cabbage, eggplant, tomatoes, turnip.

Fucose

Kelp, wakame seaweed, brewers yeast

Galactose

Dairy products, fenugreek, kelp, apple pectin, apples, apricot, banana, blackberries, cherries, cranberries, currants, dates, grapes, kiwi fruit, mango, orange, nectarine, peach, pear, pineapple, plums, prunes, raspberries, rhubarb, strawberries, passionfruit, echinacea, boswellia, chestnuts, broccoli, brussels sprouts, avocado, cabbage, carrot, cauliflower, celery, cucumber, potato, eggplant, tomatoes, leeks, asparagus, lettuce, green beans, mushrooms, beetroot, onions, parsnip, green peas, pumpkin, spinach

Glucose

Nearly all ripe fruits and vegetables, pasta, bread and all other carbohydrate foods. This sugar is abundant in most diets. Honey, grape, banana, mango, cherries, strawberry, cocoa, aloe vera, licorice, sasparila, hawthorn, garlic, echinacea, kelp - careful you can only eat to much.

N-AcetylGalactosamine

Shark cartilage, beef cartilage, chondroitin sulphate, red algae called Dumontiaceae

N-AcetylGlucosamine

Shiitake mushroom, shark cartilage, beef cartilage, glucosamine sulphate

N-AcetylNeuraminic Acid

Whey protein concentrate or isolate, chicken eggs

Xylose

Kelp, ground psyllium seeds, guava, pears, blackberries, loganberries, raspberries, aloe vera, echinacea, boswellia, broccoli, spinach, eggplant, peas, green beans, okra, cabbage, corn, xylitol.

CONCLUSION

Reclaiming you health starts at the cellular level because healthy cells = healthy bodies. The last four Nobel Prizes in Physiology or Medicine were awarded for discoveries in the field of Cellular Communication. This invaluable research has shown that the body communicates in specific ways. Science has now revealed that eight specific carbohydrate/sugar molecules called monosaccharides make up the "alphabetic code" that our cells use to communicate with each other and are not used for energy as the other more than 200 known carbohydrates does.

The eight vital monosaccharides are "essential" for building a proper inter-cellular communication system. These 8 sugars combine with cell surface proteins to form glycoproteins on the surface of every one of the trillions of cells in the body. They are the receptors and transmitters, which enables cell-to-cell communication. Without adequate amounts of all of these eight natural biologically-active "sugars", the human body cannot function properly.

When your body is missing one or more of these sugars, there is a breakdown in cellular communication which has a dramatic impact on your health and are the source of many diseases. It's like trying to communicate without the 5 vowels from the alphabet.

We only get two of these eight vital sugars from our modern day diet. We get Glucose (probably too much) and Galactose. The body is therefore forced to create the other six (Fucose, Mannose (the active ingredient in the Aloe Vera plant known for its "healing power"), N-Acetylgalactosamine, N-Acetylglucosamine, N-Acetylneurominic Acid and Xylose.

Unfortunately it is very difficult (if not impossible) for the body to continually synthesize adequate amounts of the missing sugars. It takes an enormous amount of energy - as much as 37 enzymatic steps - and anything such as stress, poor nutrition, toxins, lack of sleep, pharmaceutical drugs, auto-immune disorders or any existing illness will inhibit this process. (Did you know that 5 of the 8 necessary sugars are present in human breast milk?)

Glycobiology is the study of this group of 8 saccharides, commonly now called glyconutrients, and many books and journals have published scientific data on the power of these sugars for health and healing, e.g. Harper's Biochemistry, Acta Anatomica, Science, and M.I.T. Technology Review published glyconutrients as one of the 10 Emerging Technologies that will change the world!

Clinical studies prove that glyconutrients stimulate the development of one's bone marrow stem cells, which have the capacity to, develop into any cell the body needs, or to replace damaged tissue. Research has shown that supplementary glyconutrients can have a positive impact on a wide range of conditions, ranging from asthma, cancer, multiple sclerosis, diabetes, Alzheimer's disease, Parkinson's disease, muscular dystrophy, rheumatoid- and osteoarthritis, migraines, auto-immune disorders, burns, Hep C, gout, fibromyalgia, lupus, infertility, systemic infections, osteoporosis, PMS, sinusitis, rash, ADD & ADHD, coma, allergies... the list is endless... It has even shown that it can reverse 10 of the 12 biological markers of aging, e.g. bone density increasing.

Science has long ago proved that our bodies need proteins, fatty acids, carbohydrates, vitamins, minerals, phytonutrients and enzymes for "optimal" health. Science has now proved that we ALSO need 8 specific sugars, which are necessary for ALL cellular and immune functions, enabling the body to heal itself. The most important nutrient is the one that is missing: Glyconutrients.

The glycosciences are the last exciting frontier of biochemistry. Of the four major classes of biomolecules--proteins, nucleic acids, lipids (fats) and carbohydrates—carbohydrates are the most complex. Because of their complexity, technology has only recently developed the methods to study them, unlock their codes, and reveal their biological secrets.

As expected with any complicated field of study, the more we learn the more questions we develop. What are the precise connections between specific diseases and changes in the sugar portions of cell-surface glycoforms? How exactly does the body metabolize each of the necessary sugars when consumed in the diet? Such questions will take many years to finally resolve. The research sited in the above section on metabolism of dietary sugars is only little more than a year old. Science has only just begun to decipher the sugar (glyco) code and its importance in communicating the language of life.

While research in glycoconjugates has been ongoing in the general scientific community, pharmaceutical companies have been working to develop carbohydrate-based drugs (biologics) to treat various conditions. Several such biologics have been brought to market--numerous cytokines, for example, and erythropoietin, which is used to stimulate production of blood cells.

At the same time that interest in glycoconjugates has been growing in the scientific community and in the pharmaceutical industry, the general population has begun to pay more and more attention to nutritional intervention. Most of us are aware of scientific research that has established diet as an important component of many disease conditions. Heart disease, cancer and diabetes are obvious examples.

Glyconutritionals came about as a combination of both trends--glycoconjugate research and the focus on nutritional supplementation for health. Glyconutritionals are nutritional dietary supplements designed to provide substrates for the body to use in building the glyco portion of glycoconjugates on cell surfaces. Glyconutritionals are designed to make the necessary sugars available to the cells quicker and in greater quantity.

We have much still to learn; we have only just begun to understand the biochemical story written in the sweet language of life, but what an exciting language to learn.

1. Stryer L;. Carbohydrates. Stryer L;. Biochemistry. New York, W. H. Freeman and Company; 1995: 477-
2. Murray RK;. Glycoproteins. Murray RK;Granner DK;Mayes PA;Rodwell VW;. Harper's Biochemistry. Stamford, Appleton and Lange; 2000: 675-694

Reclaiming you health starts at the cell level because healthy cells = healthy bodies. The last four Nobel Prizes in Physiology or Medicine were awarded for discoveries in the field of Cellular Communication. This invaluable research has shown that the body communicates in specific ways. Science has now revealed that eight specific carbohydrate molecules called monosaccharides make up the "alphabetic code" that our cells use to communicate with each other and are not used for energy as the other more than 200 known carbohydrates does.

The eight vital monosaccharides are "essential" for building proper "structure". These 8 molecules combine with cell surface proteins to form glycoproteins on the surface of every one of the trillions of cells in the body. They are the receptors and transmitters, which enables cell-to-cell communication. Without adequate amounts of all these eight natural biologically-active "sugars", the human body cannot function properly.

When your body is missing one or more of these sugars, there is a breakdown in cellular communication which has a dramatic impact on your health and are the source of many diseases. It's like trying to communicate without the 5 vowels from the alphabet.

We only get two of these eight vital sugars from our modern day diet. We get Glucose (probably too much) and Galactose. The body is therefore forced to create the other six (Fucose, Mannose (the active ingredient in the Aloe Vera plant known for its "healing power"), N-Acetylgalactosamine, N-Acetylglucosamine, N-Acetylneurominic Acid and Xylose.

Unfortunately it is very difficult (if not impossible) for the body to continually synthesize adequate amounts of the missing sugars. It takes an enormous amount of energy - as much as 37 enzymatic steps - and anything such as stress, poor nutrition, toxins, lack of sleep, pharmaceutical drugs, auto-immune disorders or any existing illness will inhibit this process. (Did you know that 5 of the 8 necessary sugars are present in human breast milk?)

Glycobiology is the study of this group of 8 saccharides, commonly now called glyconutrients, and many books and journals have published scientific data on the power of these sugars for health and healing, e.g. Harper's Biochemistry, Acta Anatomica, Science, and M.I.T. Technology Review published glyconutrients as one of the 10 Emerging Technologies that will change the world!

Clinical studies prove that glyconutrients stimulate the development of one's bone marrow stem cells, which have the capacity to, develop into any cell the body needs, or to replace damaged tissue. Research has shown that supplementary glyconutrients can have a positive impact on a wide range of conditions, ranging from asthma, cancer, multiple sclerosis, diabetes, Alzheimer's disease, Parkinson's disease, muscular dystrophy, rheumatoid- and osteoarthritis, migraines, auto-immune disorders, burns, Hep C, gout, fibromyalgia, lupus, infertility, systemic infections, osteoporosis, PMS, sinusitis, rash, ADD & ADHD, coma, allergies... the list is endless... It has even shown that it can reverse 10 of the 12 biological markers of aging, e.g. bone density increasing.

Science has long ago proved that our bodies need proteins, fatty acids, carbohydrates, vitamins, minerals, phytonutrients and enzymes for "optimal" health. Science has now proved that we ALSO need 8 specific sugars, which are necessary for ALL cellular and immune functions, enabling the body to heal itself. The most important nutrient is the one that is missing: Glyconutrients.

Science has proven that your body uses glyconutrients to prevent infections and disease, and slow the aging process. The medical literature documents improvement in every major category of disease, including conditions like:

Food sources of Essential Sugars (glyconutrients)

You can adapt your diet to improve supply of “essential” sugars or supplement for a period of time to “catch up” on a deficiency. But remember there is no “magic bullet” in fixing health problems. No single nutrient or supplement, will deliver “good health” without the hard work of changing your total diet to a more nutritious one, full of its own synergistic forces. While essential sugars are very important to health, so are the other more than 90 essential nutrients.

Mannose

Aloe vera (acemannan is a chain of mannose molecules), kelp, shiitake mushroom, ground fenugreek, carob gum, guar gum, black currants, red currants, gooseberries, green beans, capsicum (cayenne pepper), cabbage, eggplant, tomatoes, turnip

Fucose

Kelp, wakame seaweed, brewers yeast

Galactose

Dairy products, fenugreek, kelp, apple pectin, apples, apricot, banana, blackberries, cherries, cranberries, currants, dates, grapes, kiwi fruit, mango, orange, nectarine, peach, pear, pineapple, plums, prunes, raspberries, rhubarb, strawberries, passionfruit, echinacea, boswellia, chestnuts, broccoli, brussels sprouts, avocado, cabbage, carrot, cauliflower, celery, cucumber, potato, eggplant, tomatoes, leeks, asparagus, lettuce, green beans, mushrooms, beetroot, onions, parsnip, green peas, pumpkin, spinach

Glucose

Nearly all ripe fruits and vegetables, pasta, bread and all other carbohydrate foods. This sugar is abundant in most diets. Honey, grape, banana, mango, cherries, strawberry, cocoa, aloe vera, licorice, sasparila, hawthorn, garlic, echinacea, kelp - careful you can only eat to much.

N-AcetylGalactosamine

Shark cartilage, beef cartilage, chondroitin sulphate, red algae called Dumontiaceae

N-AcetylGlucosamine

Shiitake mushroom, shark cartilage, beef cartilage, glucosamine sulphate

N-AcetylNeuraminic Acid

Whey protein concentrate or isolate, chicken eggs

Xylose

Kelp, ground psyllium seeds, guava, pears, blackberries, loganberries, raspberries, aloe vera, echinacea, boswellia, broccoli, spinach, eggplant, peas, green beans, okra, cabbage, corn, xylitol.

 

Disclaimer - This site amd or product information are not intended to diagnose, treat, cure or prevent any disease. The information on this Web site is designed for information and educational purposes only. It is not intended to be a substitute for informed medical advice or care. You should not use this information to diagnose or treat any health problems or illnesses without consulting your physician. Please consult a doctor with any questions or concerns you might have regarding your condition.

Copyright by www.highonlife.co.za (C) 2007